According to Greek and Roman texts Tigran II the Great (95-55 C. BC) is said to have founded four cities, bearing his name. One of those cities is located in Artsakh (Nagorno-Karabakh).

Tigranakert was mentioned for the first time in the 7th century by two Armenian historians: they report that the city might have been located on the banks of the Khashenaget River, one of the most important rivers of Artsakh, at the intersection point of the mountain range and steppe. It was also located on a busy trade route, connecting Armenia with Georgia.

Excavations at Tigranakert began again in 2006 after it was discovered in 2005. Archeologists uncovered the citadel, the Main Square and basilica. Constructions and artifacts suggest that Tigranakert was inhabited since the 1st century until the 4th century BC. The city must have been built according to a well-considered plan and is said to have displayed an architectural masterpiece.

In 2010, a museum was opened near the archeological site where the artifacts are exhibited.